diff --git a/ci/tests/Jenkinsfile.e2e-nightly b/ci/tests/Jenkinsfile.e2e-nightly
index 75156ee4e9..9c17a6d254 100644
--- a/ci/tests/Jenkinsfile.e2e-nightly
+++ b/ci/tests/Jenkinsfile.e2e-nightly
@@ -36,6 +36,12 @@ pipeline {
     ))
   }
 
+  environment {
+    /* Avoid race conditions with other builds using virtualenv. */
+    VIRTUAL_ENV = "${WORKSPACE_TMP}/venv"
+    PATH = "${VIRTUAL_ENV}/bin:${PATH}"
+  }
+
   stages {
     stage('Fetch') {
       steps { script {
@@ -52,7 +58,8 @@ pipeline {
     stage('Setup') {
       steps { script {
         dir('test/appium') {
-          sh 'pip3 install --user -r requirements.txt'
+          sh "python3 -m venv ${VIRTUAL_ENV}"
+          sh 'pip3 install -r requirements.txt'
         }
       } }
     }
diff --git a/ci/tests/Jenkinsfile.e2e-prs b/ci/tests/Jenkinsfile.e2e-prs
index 7cbf6a17c4..4dcf06b32a 100644
--- a/ci/tests/Jenkinsfile.e2e-prs
+++ b/ci/tests/Jenkinsfile.e2e-prs
@@ -54,6 +54,12 @@ pipeline {
     ))
   }
 
+  environment {
+    /* Avoid race conditions with other builds using virtualenv. */
+    VIRTUAL_ENV = "${WORKSPACE_TMP}/venv"
+    PATH = "${VIRTUAL_ENV}/bin:${PATH}"
+  }
+
   stages {
     stage('Prep') {
       steps { script {
@@ -79,7 +85,8 @@ pipeline {
     stage('Setup') {
       steps { script {
         dir('test/appium') {
-          sh 'pip3 install --user -r requirements.txt'
+          sh "python3 -m venv ${VIRTUAL_ENV}"
+          sh 'pip3 install -r requirements.txt'
         }
       } }
     }
diff --git a/ci/tests/Jenkinsfile.e2e-upgrade b/ci/tests/Jenkinsfile.e2e-upgrade
index 56ed8f9573..eeb9771bec 100644
--- a/ci/tests/Jenkinsfile.e2e-upgrade
+++ b/ci/tests/Jenkinsfile.e2e-upgrade
@@ -35,6 +35,11 @@ pipeline {
     ))
   }
 
+  environment {
+    /* Avoid race conditions with other builds using virtualenv. */
+    VIRTUAL_ENV = "${WORKSPACE_TMP}/venv"
+    PATH = "${VIRTUAL_ENV}/bin:${PATH}"
+  }
 
   stages {
     stage('Prep') {
@@ -51,7 +56,8 @@ pipeline {
     stage('Setup') {
       steps { script {
         dir('test/appium') {
-          sh 'pip3 install --user -r requirements.txt'
+          sh "python3 -m venv ${VIRTUAL_ENV}"
+          sh 'pip3 install -r requirements.txt'
         }
       } }
     }