diff --git a/README.md b/README.md
index 8c02b2d09..8f305848c 100644
--- a/README.md
+++ b/README.md
@@ -465,6 +465,18 @@ make -j$(nproc) NIMFLAGS="-d:release" USE_MULTITAIL=yes eth2_network_simulation
 make USE_LIBBACKTRACE=0 # expect the resulting binaries to be 2-3 times slower
 ```
 
+- disable `-march=native` because you want to run the binary on a different machine than the one you're building it on:
+
+```bash
+make NIMFLAGS="-d:disableMarchNative" beacon_node
+```
+
+- disable link-time optimisation (LTO):
+
+```bash
+make NIMFLAGS="-d:disableLTO" beacon_node
+```
+
 - publish a book using [mdBook](https://github.com/rust-lang/mdBook) from sources in "docs/" to GitHub pages:
 
 ```bash
diff --git a/config.nims b/config.nims
index 9d5caab4a..a7ff6468c 100644
--- a/config.nims
+++ b/config.nims
@@ -14,7 +14,7 @@ else:
 
 # `-flto` gives a significant improvement in processing speed, specially hash tree and state transition (basically any CPU-bound code implemented in nim)
 # With LTO enabled, optimization flags should be passed to both compiler and linker!
-if defined(release):
+if defined(release) and not defined(disableLTO):
   if defined(macosx): # Clang
     switch("passC", "-flto=thin")
     switch("passL", "-flto=thin")