diff --git a/config.nims b/config.nims
index 9ca740380..2b99de452 100644
--- a/config.nims
+++ b/config.nims
@@ -46,7 +46,9 @@ if defined(windows):
 # and larger arithmetic use cases, along with register starvation issues. When
 # engineering a more portable binary release, this should be tweaked but still
 # use at least -msse2 or -msse3.
-if defined(disableMarchNative):
+#
+# Apple's Clang can't handle "-march=native" on M1: https://github.com/status-im/nimbus-eth2/issues/2758
+if defined(disableMarchNative) or (defined(macosx) and defined(arm64)):
   if defined(i386) or defined(amd64):
     switch("passC", "-msse3")
     switch("passL", "-msse3")