diff --git a/packages/metro-bundler/src/Config.js b/packages/metro-bundler/src/Config.js
index e5d6f29b..1f13ff75 100644
--- a/packages/metro-bundler/src/Config.js
+++ b/packages/metro-bundler/src/Config.js
@@ -135,7 +135,7 @@ export type ConfigT = {
    * An array of modules to be required before the entry point. It should
    * contain the absolute path of each module.
    */
-  runBeforeMainModule: Array<string>,
+  getModulesRunBeforeMainModule: (entryFilePath: string) => Array<string>,
 };
 
 const DEFAULT = ({
@@ -158,7 +158,7 @@ const DEFAULT = ({
   postProcessModules: modules => modules,
   postProcessModulesForBuck: modules => modules,
   postProcessBundleSourcemap: ({code, map, outFileName}) => ({code, map}),
-  runBeforeMainModule: [],
+  getModulesRunBeforeMainModule: () => [],
   transformVariants: () => ({default: {}}),
   getWorkerPath: () => null,
 }: ConfigT);
diff --git a/packages/metro-bundler/src/Server/__tests__/Server-test.js b/packages/metro-bundler/src/Server/__tests__/Server-test.js
index 9e96c6a9..e149eea9 100644
--- a/packages/metro-bundler/src/Server/__tests__/Server-test.js
+++ b/packages/metro-bundler/src/Server/__tests__/Server-test.js
@@ -55,7 +55,7 @@ describe('processRequest', () => {
     cacheVersion: null,
     polyfillModuleNames: null,
     reporter: require('../../lib/reporting').nullReporter,
-    runBeforeMainModule: ['InitializeCore'],
+    getModulesRunBeforeMainModule: () => ['InitializeCore'],
   };
 
   const makeRequest = (reqHandler, requrl, reqOptions) =>
diff --git a/packages/metro-bundler/src/Server/index.js b/packages/metro-bundler/src/Server/index.js
index 8622288a..52700c66 100644
--- a/packages/metro-bundler/src/Server/index.js
+++ b/packages/metro-bundler/src/Server/index.js
@@ -93,7 +93,7 @@ export type Options = {|
   providesModuleNodeModules?: Array<string>,
   reporter?: Reporter,
   resetCache?: boolean,
-  +runBeforeMainModule: Array<string>,
+  +getModulesRunBeforeMainModule: (entryPoint: string) => Array<string>,
   silent?: boolean,
   +sourceExts: ?Array<string>,
   +transformCache: TransformCache,
@@ -167,7 +167,7 @@ class Server {
     providesModuleNodeModules?: Array<string>,
     reporter: Reporter,
     resetCache: boolean,
-    +runBeforeMainModule: Array<string>,
+    +getModulesRunBeforeMainModule: (entryFilePath: string) => Array<string>,
     silent: boolean,
     +sourceExts: Array<string>,
     +transformCache: TransformCache,
@@ -207,6 +207,7 @@ class Server {
           ? options.enableBabelRCLookup
           : true,
       extraNodeModules: options.extraNodeModules || {},
+      getModulesRunBeforeMainModule: options.getModulesRunBeforeMainModule,
       getPolyfills: options.getPolyfills,
       getTransformOptions: options.getTransformOptions,
       globalTransformCache: options.globalTransformCache,
@@ -223,7 +224,6 @@ class Server {
       providesModuleNodeModules: options.providesModuleNodeModules,
       reporter,
       resetCache: options.resetCache || false,
-      runBeforeMainModule: options.runBeforeMainModule,
       silent: options.silent || false,
       sourceExts: options.sourceExts || defaults.sourceExts,
       transformCache: options.transformCache,
@@ -325,7 +325,9 @@ class Server {
   async buildBundle(options: BundleOptions): Promise<Bundle> {
     const bundle = await this._bundler.bundle({
       ...options,
-      runBeforeMainModule: this._opts.runBeforeMainModule,
+      runBeforeMainModule: this._opts.getModulesRunBeforeMainModule(
+        options.entryFile,
+      ),
     });
     const modules = bundle.getModules();
     const nonVirtual = modules.filter(m => !m.virtual);
@@ -1306,7 +1308,7 @@ class Server {
       minify,
       excludeSource,
       hot: true,
-      runBeforeMainModule: this._opts.runBeforeMainModule,
+      runBeforeMainModule: this._opts.getModulesRunBeforeMainModule(entryFile),
       runModule: this._getBoolOptionFromQuery(urlObj.query, 'runModule', true),
       inlineSourceMap: this._getBoolOptionFromQuery(
         urlObj.query,
diff --git a/packages/metro-bundler/src/index.js b/packages/metro-bundler/src/index.js
index d0f7e737..3c801be1 100644
--- a/packages/metro-bundler/src/index.js
+++ b/packages/metro-bundler/src/index.js
@@ -178,6 +178,7 @@ function toServerOptions(options: Options): ServerOptions {
     cacheVersion: options.cacheVersion,
     enableBabelRCLookup: options.enableBabelRCLookup,
     extraNodeModules: options.extraNodeModules,
+    getModulesRunBeforeMainModule: options.getModulesRunBeforeMainModule,
     getPolyfills: options.getPolyfills,
     getTransformOptions: options.getTransformOptions,
     globalTransformCache: options.globalTransformCache,
@@ -193,7 +194,6 @@ function toServerOptions(options: Options): ServerOptions {
     providesModuleNodeModules: options.providesModuleNodeModules,
     reporter: options.reporter,
     resetCache: options.resetCache,
-    runBeforeMainModule: options.runBeforeMainModule,
     silent: options.silent,
     sourceExts: options.sourceExts,
     transformCache: options.transformCache || TransformCaching.useTempDir(),