diff --git a/evm/src/cpu/columns/ops.rs b/evm/src/cpu/columns/ops.rs
index b8a4d8a6..d4d753f7 100644
--- a/evm/src/cpu/columns/ops.rs
+++ b/evm/src/cpu/columns/ops.rs
@@ -28,9 +28,7 @@ pub struct OpsColumnsView<T: Copy> {
     pub mstore_32bytes: T,
     pub mload_32bytes: T,
     pub exit_kernel: T,
-    // TODO: combine MLOAD_GENERAL and MSTORE_GENERAL into one flag
-    pub mload_general: T,
-    pub mstore_general: T,
+    pub m_op_general: T,
 
     pub syscall: T,
     pub exception: T,
diff --git a/evm/src/cpu/control_flow.rs b/evm/src/cpu/control_flow.rs
index 8d0ee264..eeabf6f0 100644
--- a/evm/src/cpu/control_flow.rs
+++ b/evm/src/cpu/control_flow.rs
@@ -8,7 +8,7 @@ use crate::constraint_consumer::{ConstraintConsumer, RecursiveConstraintConsumer
 use crate::cpu::columns::{CpuColumnsView, COL_MAP};
 use crate::cpu::kernel::aggregator::KERNEL;
 
-const NATIVE_INSTRUCTIONS: [usize; 18] = [
+const NATIVE_INSTRUCTIONS: [usize; 17] = [
     COL_MAP.op.binary_op,
     COL_MAP.op.ternary_op,
     COL_MAP.op.fp254_op,
@@ -29,8 +29,7 @@ const NATIVE_INSTRUCTIONS: [usize; 18] = [
     COL_MAP.op.swap,
     COL_MAP.op.context_op,
     // not EXIT_KERNEL (performs a jump)
-    COL_MAP.op.mload_general,
-    COL_MAP.op.mstore_general,
+    COL_MAP.op.m_op_general,
     // not SYSCALL (performs a jump)
     // not exceptions (also jump)
 ];
diff --git a/evm/src/cpu/cpu_stark.rs b/evm/src/cpu/cpu_stark.rs
index 1579b3a1..2d2e9072 100644
--- a/evm/src/cpu/cpu_stark.rs
+++ b/evm/src/cpu/cpu_stark.rs
@@ -246,7 +246,7 @@ impl<F: RichField + Extendable<D>, const D: usize> Stark<F, D> for CpuStark<F, D
         gas::eval_packed(local_values, next_values, yield_constr);
         jumps::eval_packed(local_values, next_values, yield_constr);
         membus::eval_packed(local_values, yield_constr);
-        memio::eval_packed(local_values, yield_constr);
+        memio::eval_packed(local_values, next_values, yield_constr);
         modfp254::eval_packed(local_values, yield_constr);
         pc::eval_packed(local_values, yield_constr);
         push0::eval_packed(local_values, yield_constr);
@@ -273,7 +273,7 @@ impl<F: RichField + Extendable<D>, const D: usize> Stark<F, D> for CpuStark<F, D
         gas::eval_ext_circuit(builder, local_values, next_values, yield_constr);
         jumps::eval_ext_circuit(builder, local_values, next_values, yield_constr);
         membus::eval_ext_circuit(builder, local_values, yield_constr);
-        memio::eval_ext_circuit(builder, local_values, yield_constr);
+        memio::eval_ext_circuit(builder, local_values, next_values, yield_constr);
         modfp254::eval_ext_circuit(builder, local_values, yield_constr);
         pc::eval_ext_circuit(builder, local_values, yield_constr);
         push0::eval_ext_circuit(builder, local_values, yield_constr);
diff --git a/evm/src/cpu/decode.rs b/evm/src/cpu/decode.rs
index cc87281c..c1c43a0b 100644
--- a/evm/src/cpu/decode.rs
+++ b/evm/src/cpu/decode.rs
@@ -1,5 +1,6 @@
 use plonky2::field::extension::Extendable;
 use plonky2::field::packed::PackedField;
+use plonky2::field::types::Field;
 use plonky2::hash::hash_types::RichField;
 use plonky2::iop::ext_target::ExtensionTarget;
 
@@ -22,7 +23,7 @@ use crate::cpu::columns::{CpuColumnsView, COL_MAP};
 /// behavior.
 /// Note: invalid opcodes are not represented here. _Any_ opcode is permitted to decode to
 /// `is_invalid`. The kernel then verifies that the opcode was _actually_ invalid.
-const OPCODES: [(u8, usize, bool, usize); 18] = [
+const OPCODES: [(u8, usize, bool, usize); 16] = [
     // (start index of block, number of top bits to check (log2), kernel-only, flag column)
     // ADD, MUL, SUB, DIV, MOD, LT, GT and BYTE flags are handled partly manually here, and partly through the Arithmetic table CTL.
     // ADDMOD, MULMOD and SUBMOD flags are handled partly manually here, and partly through the Arithmetic table CTL.
@@ -45,19 +46,19 @@ const OPCODES: [(u8, usize, bool, usize); 18] = [
     (0xf6, 1, true, COL_MAP.op.context_op), // 0xf6-0xf7
     (0xf8, 0, true, COL_MAP.op.mload_32bytes),
     (0xf9, 0, true, COL_MAP.op.exit_kernel),
-    (0xfb, 0, true, COL_MAP.op.mload_general),
-    (0xfc, 0, true, COL_MAP.op.mstore_general),
+    // MLOAD_GENERAL and MSTORE_GENERAL flags are handled manually here.
 ];
 
 /// List of combined opcodes requiring a special handling.
 /// Each index in the list corresponds to an arbitrary combination
 /// of opcodes defined in evm/src/cpu/columns/ops.rs.
-const COMBINED_OPCODES: [usize; 5] = [
+const COMBINED_OPCODES: [usize; 6] = [
     COL_MAP.op.logic_op,
     COL_MAP.op.fp254_op,
     COL_MAP.op.binary_op,
     COL_MAP.op.ternary_op,
     COL_MAP.op.shift,
+    COL_MAP.op.m_op_general,
 ];
 
 pub fn generate<F: RichField>(lv: &mut CpuColumnsView<F>) {
@@ -99,6 +100,10 @@ pub fn generate<F: RichField>(lv: &mut CpuColumnsView<F>) {
         let flag = available && opcode_match;
         lv[col] = F::from_bool(flag);
     }
+
+    if opcode == 0xfb || opcode == 0xfc {
+        lv.op.m_op_general = F::from_bool(kernel);
+    }
 }
 
 /// Break up an opcode (which is 8 bits long) into its eight bits.
@@ -173,6 +178,20 @@ pub fn eval_packed_generic<P: PackedField>(
         // correct mode.
         yield_constr.constraint(lv[col] * (unavailable + opcode_mismatch));
     }
+
+    // Manually check lv.op.m_op_constr
+    let opcode: P = lv
+        .opcode_bits
+        .into_iter()
+        .enumerate()
+        .map(|(i, bit)| bit * P::Scalar::from_canonical_u64(1 << i))
+        .sum();
+    yield_constr.constraint((P::ONES - kernel_mode) * lv.op.m_op_general);
+
+    let m_op_constr = (opcode - P::Scalar::from_canonical_usize(0xfb_usize))
+        * (opcode - P::Scalar::from_canonical_usize(0xfc_usize))
+        * lv.op.m_op_general;
+    yield_constr.constraint(m_op_constr);
 }
 
 pub fn eval_ext_circuit<F: RichField + Extendable<D>, const D: usize>(
@@ -251,4 +270,28 @@ pub fn eval_ext_circuit<F: RichField + Extendable<D>, const D: usize>(
         let constr = builder.mul_extension(lv[col], constr);
         yield_constr.constraint(builder, constr);
     }
+
+    // Manually check lv.op.m_op_constr
+    let opcode = lv
+        .opcode_bits
+        .into_iter()
+        .rev()
+        .fold(builder.zero_extension(), |cumul, bit| {
+            builder.mul_const_add_extension(F::TWO, cumul, bit)
+        });
+
+    let mload_opcode = builder.constant_extension(F::Extension::from_canonical_usize(0xfb_usize));
+    let mstore_opcode = builder.constant_extension(F::Extension::from_canonical_usize(0xfc_usize));
+
+    let one_extension = builder.constant_extension(F::Extension::ONE);
+    let is_not_kernel_mode = builder.sub_extension(one_extension, kernel_mode);
+    let constr = builder.mul_extension(is_not_kernel_mode, lv.op.m_op_general);
+    yield_constr.constraint(builder, constr);
+
+    let mload_constr = builder.sub_extension(opcode, mload_opcode);
+    let mstore_constr = builder.sub_extension(opcode, mstore_opcode);
+    let mut m_op_constr = builder.mul_extension(mload_constr, mstore_constr);
+    m_op_constr = builder.mul_extension(m_op_constr, lv.op.m_op_general);
+
+    yield_constr.constraint(builder, m_op_constr);
 }
diff --git a/evm/src/cpu/gas.rs b/evm/src/cpu/gas.rs
index a4a499ad..51f375c0 100644
--- a/evm/src/cpu/gas.rs
+++ b/evm/src/cpu/gas.rs
@@ -40,8 +40,7 @@ const SIMPLE_OPCODES: OpsColumnsView<Option<u32>> = OpsColumnsView {
     mstore_32bytes: KERNEL_ONLY_INSTR,
     mload_32bytes: KERNEL_ONLY_INSTR,
     exit_kernel: None,
-    mload_general: KERNEL_ONLY_INSTR,
-    mstore_general: KERNEL_ONLY_INSTR,
+    m_op_general: KERNEL_ONLY_INSTR,
     syscall: None,
     exception: None,
 };
diff --git a/evm/src/cpu/memio.rs b/evm/src/cpu/memio.rs
index 09490e87..aa3749ca 100644
--- a/evm/src/cpu/memio.rs
+++ b/evm/src/cpu/memio.rs
@@ -7,6 +7,7 @@ use plonky2::iop::ext_target::ExtensionTarget;
 use crate::constraint_consumer::{ConstraintConsumer, RecursiveConstraintConsumer};
 use crate::cpu::columns::CpuColumnsView;
 use crate::cpu::membus::NUM_GP_CHANNELS;
+use crate::cpu::stack;
 
 fn get_addr<T: Copy>(lv: &CpuColumnsView<T>) -> (T, T, T) {
     let addr_context = lv.mem_channels[0].value[0];
@@ -17,9 +18,11 @@ fn get_addr<T: Copy>(lv: &CpuColumnsView<T>) -> (T, T, T) {
 
 fn eval_packed_load<P: PackedField>(
     lv: &CpuColumnsView<P>,
+    nv: &CpuColumnsView<P>,
     yield_constr: &mut ConstraintConsumer<P>,
 ) {
-    let filter = lv.op.mload_general;
+    // The opcode for MLOAD_GENERAL is 0xfb. If the operation is MLOAD_GENERAL, lv.opcode_bits[0] = 1
+    let filter = lv.op.m_op_general * lv.opcode_bits[0];
 
     let (addr_context, addr_segment, addr_virtual) = get_addr(lv);
 
@@ -38,14 +41,25 @@ fn eval_packed_load<P: PackedField>(
     for &channel in &lv.mem_channels[4..NUM_GP_CHANNELS - 1] {
         yield_constr.constraint(filter * channel.used);
     }
+
+    // Stack constraints
+    stack::eval_packed_one(
+        lv,
+        nv,
+        filter,
+        stack::MLOAD_GENERAL_OP.unwrap(),
+        yield_constr,
+    );
 }
 
 fn eval_ext_circuit_load<F: RichField + Extendable<D>, const D: usize>(
     builder: &mut plonky2::plonk::circuit_builder::CircuitBuilder<F, D>,
     lv: &CpuColumnsView<ExtensionTarget<D>>,
+    nv: &CpuColumnsView<ExtensionTarget<D>>,
     yield_constr: &mut RecursiveConstraintConsumer<F, D>,
 ) {
-    let filter = lv.op.mload_general;
+    let mut filter = lv.op.m_op_general;
+    filter = builder.mul_extension(filter, lv.opcode_bits[0]);
 
     let (addr_context, addr_segment, addr_virtual) = get_addr(lv);
 
@@ -82,13 +96,24 @@ fn eval_ext_circuit_load<F: RichField + Extendable<D>, const D: usize>(
         let constr = builder.mul_extension(filter, channel.used);
         yield_constr.constraint(builder, constr);
     }
+
+    // Stack constraints
+    stack::eval_ext_circuit_one(
+        builder,
+        lv,
+        nv,
+        filter,
+        stack::MLOAD_GENERAL_OP.unwrap(),
+        yield_constr,
+    );
 }
 
 fn eval_packed_store<P: PackedField>(
     lv: &CpuColumnsView<P>,
+    nv: &CpuColumnsView<P>,
     yield_constr: &mut ConstraintConsumer<P>,
 ) {
-    let filter = lv.op.mstore_general;
+    let filter = lv.op.m_op_general * (P::ONES - lv.opcode_bits[0]);
 
     let (addr_context, addr_segment, addr_virtual) = get_addr(lv);
 
@@ -107,14 +132,27 @@ fn eval_packed_store<P: PackedField>(
     for &channel in &lv.mem_channels[5..] {
         yield_constr.constraint(filter * channel.used);
     }
+
+    // Stack constraints
+    stack::eval_packed_one(
+        lv,
+        nv,
+        filter,
+        stack::MSTORE_GENERAL_OP.unwrap(),
+        yield_constr,
+    );
 }
 
 fn eval_ext_circuit_store<F: RichField + Extendable<D>, const D: usize>(
     builder: &mut plonky2::plonk::circuit_builder::CircuitBuilder<F, D>,
     lv: &CpuColumnsView<ExtensionTarget<D>>,
+    nv: &CpuColumnsView<ExtensionTarget<D>>,
     yield_constr: &mut RecursiveConstraintConsumer<F, D>,
 ) {
-    let filter = lv.op.mstore_general;
+    let mut filter = lv.op.m_op_general;
+    let one = builder.one_extension();
+    let minus = builder.sub_extension(one, lv.opcode_bits[0]);
+    filter = builder.mul_extension(filter, minus);
 
     let (addr_context, addr_segment, addr_virtual) = get_addr(lv);
 
@@ -151,21 +189,33 @@ fn eval_ext_circuit_store<F: RichField + Extendable<D>, const D: usize>(
         let constr = builder.mul_extension(filter, channel.used);
         yield_constr.constraint(builder, constr);
     }
+
+    // Stack constraints
+    stack::eval_ext_circuit_one(
+        builder,
+        lv,
+        nv,
+        filter,
+        stack::MSTORE_GENERAL_OP.unwrap(),
+        yield_constr,
+    );
 }
 
 pub fn eval_packed<P: PackedField>(
     lv: &CpuColumnsView<P>,
+    nv: &CpuColumnsView<P>,
     yield_constr: &mut ConstraintConsumer<P>,
 ) {
-    eval_packed_load(lv, yield_constr);
-    eval_packed_store(lv, yield_constr);
+    eval_packed_load(lv, nv, yield_constr);
+    eval_packed_store(lv, nv, yield_constr);
 }
 
 pub fn eval_ext_circuit<F: RichField + Extendable<D>, const D: usize>(
     builder: &mut plonky2::plonk::circuit_builder::CircuitBuilder<F, D>,
     lv: &CpuColumnsView<ExtensionTarget<D>>,
+    nv: &CpuColumnsView<ExtensionTarget<D>>,
     yield_constr: &mut RecursiveConstraintConsumer<F, D>,
 ) {
-    eval_ext_circuit_load(builder, lv, yield_constr);
-    eval_ext_circuit_store(builder, lv, yield_constr);
+    eval_ext_circuit_load(builder, lv, nv, yield_constr);
+    eval_ext_circuit_store(builder, lv, nv, yield_constr);
 }
diff --git a/evm/src/cpu/stack.rs b/evm/src/cpu/stack.rs
index 765a7a07..28abf077 100644
--- a/evm/src/cpu/stack.rs
+++ b/evm/src/cpu/stack.rs
@@ -44,6 +44,18 @@ pub(crate) const JUMPI_OP: Option<StackBehavior> = Some(StackBehavior {
     disable_other_channels: false,
 });
 
+pub(crate) const MLOAD_GENERAL_OP: Option<StackBehavior> = Some(StackBehavior {
+    num_pops: 3,
+    pushes: true,
+    disable_other_channels: false,
+});
+
+pub(crate) const MSTORE_GENERAL_OP: Option<StackBehavior> = Some(StackBehavior {
+    num_pops: 4,
+    pushes: false,
+    disable_other_channels: false,
+});
+
 // AUDITORS: If the value below is `None`, then the operation must be manually checked to ensure
 // that every general-purpose memory channel is either disabled or has its read flag and address
 // propertly constrained. The same applies  when `disable_other_channels` is set to `false`,
@@ -107,16 +119,7 @@ const STACK_BEHAVIORS: OpsColumnsView<Option<StackBehavior>> = OpsColumnsView {
         pushes: false,
         disable_other_channels: true,
     }),
-    mload_general: Some(StackBehavior {
-        num_pops: 3,
-        pushes: true,
-        disable_other_channels: false,
-    }),
-    mstore_general: Some(StackBehavior {
-        num_pops: 4,
-        pushes: false,
-        disable_other_channels: false,
-    }),
+    m_op_general: None,
     syscall: Some(StackBehavior {
         num_pops: 0,
         pushes: true,
diff --git a/evm/src/witness/transition.rs b/evm/src/witness/transition.rs
index 9532aa33..e3e7b584 100644
--- a/evm/src/witness/transition.rs
+++ b/evm/src/witness/transition.rs
@@ -179,8 +179,7 @@ fn fill_op_flag<F: Field>(op: Operation, row: &mut CpuColumnsView<F>) {
         Operation::Mload32Bytes => &mut flags.mload_32bytes,
         Operation::Mstore32Bytes => &mut flags.mstore_32bytes,
         Operation::ExitKernel => &mut flags.exit_kernel,
-        Operation::MloadGeneral => &mut flags.mload_general,
-        Operation::MstoreGeneral => &mut flags.mstore_general,
+        Operation::MloadGeneral | Operation::MstoreGeneral => &mut flags.m_op_general,
     } = F::ONE;
 }