diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index f84b3a420..560073899 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -188,8 +188,8 @@ jobs:
           NIM_PARAMS=""
           if [[ '${{ runner.os }}' == 'macOS' ]]; then
             case "$(uname -m)" in
-              x86_64)  NIM_PARAMS="--cpu:amd64" ;;
-              arm64)   NIM_PARAMS="--cpu:arm64" ;;
+              x86_64)  NIM_PARAMS="--cpu:amd64 -d:disableMarchNative" ;;
+              arm64)   NIM_PARAMS="--cpu:arm64 -d:disableMarchNative" ;;
             esac
           fi
           make V=1 QUICK_AND_DIRTY_COMPILER=1 NIM_PARAMS="${NIM_PARAMS}" USE_LIBBACKTRACE=0 all
@@ -345,8 +345,8 @@ jobs:
           NIM_PARAMS=""
           if [[ '${{ runner.os }}' == 'macOS' ]]; then
             case "$(uname -m)" in
-              x86_64)  NIM_PARAMS="--cpu:amd64" ;;
-              arm64)   NIM_PARAMS="--cpu:arm64" ;;
+              x86_64)  NIM_PARAMS="--cpu:amd64 -d:disableMarchNative" ;;
+              arm64)   NIM_PARAMS="--cpu:arm64 -d:disableMarchNative" ;;
             esac
           fi
 
diff --git a/config.nims b/config.nims
index 8e50cfecf..9bc305a4e 100644
--- a/config.nims
+++ b/config.nims
@@ -54,7 +54,7 @@ if defined(disableMarchNative):
 elif defined(macosx) and defined(amd64):
   switch("passC", "-march=native")
   switch("passL", "-march=native")
-elif defined(macosx) and defined(arm64):
+elif defined(macosx) and defined(arm64) and not defined(disableMarchNative):
   # Apple's Clang can't handle "-march=native" on M1: https://github.com/status-im/nimbus-eth2/issues/2758
   switch("passC", "-mcpu=apple-m1")
   switch("passL", "-mcpu=apple-m1")